The 8 Main Causes of Sweet’s Syndrome
The Main Causes of Sweet Syndrome that we should not ignore. In addition, Sweet’s syndrome (also known as acute febrile neutral philic dermatosis) is an uncommon skin disorder characterized by fever and the appearance of soft red lumps on the skin. It is a reactive condition with several potential triggers. It is not contagious and cannot be transferred from one person to another. So, check now The 8 Main Causes of Sweet Syndrome:
Causes of Sweet Syndrome: Most of the time, Sweet Syndrome happens on its own and doctors cannot find the cause. Other times, it happens when your immune system reacts to another problem, such as:
- Blood cancer such as leukemia or lymphoma
- Bowel disease, such as ulcerative colitis or Crohn’s disease
- chest infection
- Colon Cancer
- Breast cancer
- Wound where the rash is, such as a needle prick or insect bite
- Rheumatoid arthritis
A drug reaction can also bring on Sweet’s Syndrome . Possible medications include common medications such as nonsteroidal anti-inflammatory drugs (Advil, Motrin). But a drug called granulocyte colony-stimulating factor that is used to help fight infections in some people with cancer is the most common culprit.
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Symptoms of Sweet’s Syndrome: Sweet ‘s Syndrome can cause some or all of the following symptoms to appear together over a period of hours or a few days. The main symptoms of Sweet Syndrome :
- A rash (described above)
- Tiredness, lack of energy and feeling unwell
- High fever (temperature)
- Sore joints and muscles
- Mouth ulcers
- eye pain
Diagnosis of Sweet’s Syndrome: A skin biopsy performed by a dermatologist usually confirms the diagnosis of Sweet’s Syndrome . This shows neutrophils, some breaking down, getting into the top layer of the skin, particularly around blood vessels. Blood vessels can be damaged by chemicals released by neutrophils.
Blood tests are used to confirm an elevated white cell and neutrophil count. Blood tests also show inflammatory markers such as ESR (erythrocyte sedimentation rate) as being raised. Other tests such as urinalysis, bone marrow tests, cancer screenings, and imaging studies (x-rays, CT scans) and tests to rule out infection are sometimes needed to look for conditions associated with Sweet’s Syndrome .
Sweet’s Syndrome Treatments: Sweet ‘s Syndrome is treated by trying to identify and cure any underlying or associated disorder. In more than 50% of cases, no underlying medical cause or association is found and the condition is treated with corticosteroid tablets (prednisone or prednisolone). Generally, rapid improvement is expected and the corticosteroid dosage is gradually reduced over several weeks or months.
Corticosteroids can be applied as a cream or injected into areas of Sweet’s Syndrome in mild localized cases. Alternative treatments may be used in cases where corticosteroids are not effective or safe (eg, the presence of a serious infection). In small studies, a good response to indometicin and colchicine or potassium iodide was reported.
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People with Sweet’s Syndrome have responded well to other drugs that affect neutrophil function, including: “anti-infective” agents (eg, dapsone, clofazimine, metronidazole, or doxycycline); Retinoids (eg isotretinoin); Pentoxifylline and thalidomide; Immunosuppressive and cytotoxic agents (eg, methotrexate, cyclosporine, chlorambucil) and biological agents.