Dipyrone – indications, how to use and side effects!

Dipyrone is a remedy that has  several types of use for its use. It is widely used because of its beneficial analgesic effects that can relieve pain of various types.

Caused by flu or colds for example, it is very efficient in these cases, not to mention the speed of the contained effect, which is very fast after use, then the relief of body temperatures lowering, the headache , body pain going away.

The effects of the medicine that controls pain and the antipyretic activities of the body will be expected from 30 to 60 minutes after being ingested, general-salgadense staying in the body for approximately 4 hours after use.

What is dipyrone?

Dipyrone is a popular pain relief medication in some countries and is used to treat post-operative pain, colic pain (sharp stomach pain), cancer pain and migraine ( severe headache ).

How to use dipyrone?

Take the tablets with liquid (approximately ½ to 1 glass) orally. This medicine must not be chewed. In principle, the chosen dose and route of administration depend on the desired analgesic effect and the patient’s condition. In many cases, oral or rectal administration is sufficient to obtain satisfactory analgesia.

When rapid onset analgesic effect is required or when oral or rectal administration is contraindicated, intravenous or intramuscular administration is recommended. The treatment can be interrupted at any time without causing harm to the patient, inherent to the withdrawal of the medication.

What is dipyrone used for?

Dipyrone has analgesic, spasmolytic, and antipyretic effects and is used to treat pain. Due to a possible risk of agranulocytosis, it has been banned in several countries. The most used data for the use of dipyrone are related to adults.

Given the potential added value of dipyrone in the treatment of pain, a literature review was performed to obtain more information on analgesic efficacy in children, as well as safety in terms of adverse events.

A bibliographic search was carried out for original articles (in English, German or Spanish), which met the following criteria: use of dipyrone for pain and children up to 17 years of age. All retrieved titles and abstracts were independently reviewed by two of the authors for suitability for inclusion.

The references of selected articles were also checked for additional relevant articles. Publications were categorized into case reports, observational studies or randomized clinical trials. .

In the limited data available, the analgesic efficacy of intravenous dipyrone appears similar to that of intravenous paracetamol. Evidence is lacking to support the claim it is equivalent or even superior to nonsteroidal anti-inflammatory drugs in pediatric pain.

How does dipyrone work in the body?

The analgesic effect of certain dipyrone is probably due to the inhibition of central cyclooxygenase. The exact mechanism has not yet been fully clarified. Cyclooxygenases are involved in the synthesis of prostaglandins, which lower the excitation threshold of painful fibers.

Thus, they make nociceptors more sensitive to painful stimuli. If, as in the case of dipyrone , synthesis of prostaglandins in the dorsal horn of the spinal cord is inhibited, nociceptors become less sensitive to pain mediators.

The results of the study suggest that the metabolites can also bind to cannabinoid type 1 receptors. These receptors are part of the descending antinociceptive system and are responsible for the reduction of energetic GABA transmissions in the substantia grisea periaquaeductalis. An analgesic involvement of the TRPA1 channel has been demonstrated in animal models.

When correct and morphine are given simultaneously, dipyrone enhances the analgesic effect of morphine. Postoperatively, this combination can reduce the required doses of morphine in many patients. However, the exact mechanism has not yet been conclusively clarified.

What is the right way to take dipyrone?

Dipyrone can be administered orally or rectally as tablets, drops or suppositories. Alternatively, it can be administered slowly parenterally by intravenous or intramuscular injections under control of pulse, respiration and blood pressure. With parenteral administration, however, it should be borne in mind that the risk of serious side effects is greater.

Single dose:
The single dose is 500-1000 mg for adults and adolescents aged 15 years and over and 500 mg for children aged 10 to 14 years.

Maximum daily dose:
The maximum daily dose is 5000 mg for adults and adolescents aged 15 years and 2000 mg for children aged 10 to 14 years.

Who should not use di pirone?

Dipyrone is contraindicated in pregnancy, breastfeeding, and in people with allergies to dipyrone sodium or any of the components of the formula, asthma, acute intermittent liver porphyria, and congenital glucose-6-phosphate dehydrogenase deficiency.

Patients who have developed bronchospasm or other anaphylactic reactions with analgesics such as salicylates, paracetamol, diclofenac, ibuprofen, indomethacin and naproxen.

Dipyrone interactions:

  • Hypothermia can occur when dipyrone and chlorpromazine are used at the same time;
  • Simultaneous treatment of dipyrone with methotrexate may increase the hematotoxicity of methotrexate. This combination should be avoided.
  • Care should be taken with concurrent treatment with low-dose acetylsalicylic acid for prophylaxis of heart disease, as the effect of acetylsalicylic acid on platelet aggregation may be weakened.
  • Likewise, bupropion should be used with caution at the same time, as interactions can lead to a lower level of bupropion in the blood.
  • Interactions with oral anticoagulants, captopril, lithium and triamters, as well as antihypertensives and diuretics, are known by the pyrazolones class of substances;
  • The specific influence on these drugs is unknown.

Dipyrone side effects:

Dipyrone  is a very strong medicine, its use can cause many side effects in people who ingest it. It is very common for people to have a drop in blood pressure for people who have uncontrolled heart problems and are experiencing dehydration.

In many countries use has been found to cause agranulocytosis. Agranulocytosis occurs when there is a large drop in white blood cells, which are an immune cell responsible for fighting invading germs.

Contraindications : _

Most medicines in the world have their contraindications for some people. Anyone who has or has patients who have allergies to any component that has in the formula is not recommended to use.

It is contraindicated for children who are less than 3 months old, or weighing less than 5 kg. In addition, women who are pregnant are not recommended to use it, those who are breastfeeding their children as well.

People who should not use it, who have some kind of alteration, for example: those who have problems with bone marrow functioning, breathing difficulties or even allergic rhinitis , congenital deficiency of glucose-6-phosphate-dehydrogenase and hepatic porphyria.

Similar Posts