Cycloprimogyna leaflet: how to use? what is it for and side effect!

Cicloprimogyna is a drug intended for hormone replacement therapy (HRT) to relieve symptoms associated with menopause. It is also used to treat menstrual cycle changes . Cicloprimogyna also acts to combat cysts , making the cysts  can be eliminated during menstruation , instead of proceeding with an extraction surgery. Talk to your doctor to get more information about the action of the product and its use.

Hormone regulation therapy is something that many women need, which is why there are several drugs developed to help with this process, such as Cicloprimogyna .


Cicloprimogyna is indicated for hormone replacement therapy (HRT) for the treatment of signs and symptoms of estrogen deficiency due to natural menopause or hypogonadism, oophorectomy or primary ovarian failure in women with an intact uterus  , control of menstrual cycle irregularities , treatment of amenorrhea primary and secondary.

How to use:

To start using Cicloprimogyna , if you are still menstruating, you must start Cicloprimogyna treatment on the fifth day of your menstrual cycle , noting that the first day of your menstrual cycle corresponds to the first day of menstrual bleeding. Follow your doctor’s advice for starting treatment if you are not menstruating, or if your menstrual cycles are very irregular.

The Cicloprimogyna pack contains 21 tablets, arranged in numerical sequence and colors. Take 1 tablet of Cicloprimogyna   daily, starting with the number 1 (white) pill marked below the word “Start” and continue taking one pill daily, following the direction of the arrows until you take the last pill (reddish-brown). Once the 21 days are complete, take a 7-day break.

Take  Cicloprimogyna tablets whole, with a small amount of liquid, without chewing and preferably at the same time of day. During the break interval, a few days after taking the last pill, menstruation-like bleeding usually occurs .

After this 7-day interval, restart treatment with a new pack of Cicloprimogyna , regardless of whether the bleeding has stopped or not. Note that the start of each new pack will always be on the same day of the week as the previous pack.

How it works:

Cicloprimogyna is composed of two different types of hormones , which are levonorgestrel (which is a progestin) and estradiol valerate, which work by replacing the hormones that the body stops producing.

Estradiol is a hormone that works by preventing and relieving symptoms caused by menopause, such as feelings of heat, irritation, sleep disturbances, headaches, vaginal dryness and others. Levonorgestrel, on the other hand, works by preventing the thickening of the inner layer that lines the uterus from occurring .


Cicloprimogyna is contraindicated in case of:

  • Pregnancy or breastfeeding;
  • Vaginal bleeding of unknown cause;
  • Presence or suspicion of breast cancer;
  • Presence or suspicion of cancer that can develop under the influence of  sex hormones ;
  • Presence or history of liver tumor (benign or malignant);
  • Severe liver disease ;
  • Recent history of heart attack and/or stroke;
  • Current or previous history of thrombosis (blood clot formation) in the blood vessels of the legs ( deep vein thrombosis  ) or lungs (pulmonary embolism);
  • Very high levels of a special type of fat (triglycerides) in the blood;
  • Hypersensitivity to any of the components of Cicloprimogyna .

If any of these conditions arise for the first time during hormone replacement therapy with Cicloprimogyna , discontinue use immediately and consult your physician.


Attention, this medicine contains sugar, therefore, it should be used with caution in patients with diabetes . Cicloprimogyna cannot be used as a contraceptive. When necessary, contraception should be performed with non-hormonal methods, with the exception of rhythm and temperature methods. If pregnancy is suspected , therapy should be discontinued until this possibility is excluded (see “ Pregnancy and lactation”).

What to do if you forget to take it:

If you forget to take a Cicloprimogyna tablet , take it as soon as possible. If the delay is more than 24 hours, no additional pills should be taken. Bleeding may occur if several pills are forgotten.

Side effects:

Adverse reactions resulting from the use of cycloprimogyne are as follows, according to their occurrence. Common adverse reactions (occurring between 1 and 9 people in 100):

  • Increase or elevation of body weight;
  • Headache ;
  • Abdominal pain;
  • nausea;
  • Skin rashes;
  • itching ;
  • Vaginal bleeding, including irregular bleeding.

How to drink:

For those who still menstruate, the beginning of the use of cicloprimogyna should be done on the 5th day of the menstrual cycle , considering that the 1st day of the cycle is the one in which menstruation occurs . However, if there is no longer a menstrual cycle or if they are irregular, it is necessary to follow the medical indication to start treatment. Each cycloprimogyna pack contains 21 tablets, 11 of which are white and 10 reddish-brown, which are in numerical sequence, starting with the number 1, which is the tablet with the beginning marking.

Useful links: 

Then, you should take only one pill a day, according to the arrows and numbers, until you complete the 21 days, taking a break of 7 days and then starting a new pack again. Always follow your doctor’s advice regarding the timing, dosage, and duration of treatment. Cicloprimogyna should not be broken, opened or chewed.

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