Black Pepper and White Pepper – Main Drug Interactions

Black Pepper and White Pepper – Main Drug Interactions . Also,  black pepper and white pepper are made from the Piper nigrum plant. Black pepper is ground from dried, whole and unripe fruits. White pepper is ground from dried, ripe fruit that has had the outer layer removed. Black pepper and white pepper powder are used to make medicine.

People take black pepper to fight stomach problems, bronchitis and cancer. White pepper is used for stomach problems, malaria , cholera and cancer .

Black pepper is sometimes applied directly to the skin to treat nerve pain (neuralgia) and a skin condition called scabies. Additionally, both are used topically to relieve pain.

In foods and beverages, black pepper, white pepper and chili oil (a product distilled from black peppercorns) are used as flavoring agents.

How it works?

Both varieties of chili peppers can fight germs (microbes) that affect the stomach as it is able to increase the flow of digestive juices. Additionally, there is conflicting evidence about its role in cancer . Some evidence suggests that chili peppers may protect against colon cancer , but other evidence suggests that it may promote liver cancer .

Check out some uses and effectiveness of black pepper and white pepper: 

  • Inflammation of the airways (bronchitis);
  • Malaria and cholera;
  • upset stomach;
  • Cancer;
  • Dor;
  • Sarna;
  • Other problems.

Side Effects and Necessary Care: 

Black pepper and white pepper are both safe, in which case they can be safe for most people when used in medicinal amounts.

Pepper can have a burning taste. In this case, taking large amounts of black and white pepper by mouth, may accidentally enter the lungs, this has been reported as a cause of death. This fact is especially true when it comes to children.

Black pepper and white pepper , when applied directly to the skin, are safe for most adults. However, there is not enough information on whether use on the skin is safe for children. Because when used topically, these peppers can also cause redness and burning if they come in contact with the eyes.

Special Precautions and Warnings:

Pregnancy and Breastfeeding:

It is okay to use black and white pepper in the amount of food if you are pregnant . But taking larger amounts can be unsafe. There is a concern that black pepper in large amounts could cause a miscarriage .

Also, avoid putting pepper on your skin. Not enough is known about the safety of using this pepper topically during pregnancy.

If you are breastfeeding, limit your consumption of chili peppers. Not enough is known about the safety of using larger medicinal amounts.

Black Pepper and White Pepper → Drug Interactions: 


Black pepper and white pepper can have a “ diuretic ” effect. Taking black pepper and white pepper can decrease how much the body gets rid of lithium . This can increase the amount of lithium in the body and result in serious side effects.

In that case, talk to your doctor before using this product if you are taking lithium. Your lithium dose may need to be changed.

Drugs Metabolized by the Liver (Cytochrome P450 3A4 (CYP3A4) substrates): 

Some drugs are modified and broken down by the liver. Black and white pepper can decrease how quickly the liver breaks down some medications. Taking chili peppers along with some medications that are broken down by the liver can increase the chance of side effects from some medications.

Before taking black or white pepper, talk to your doctor if you are taking any medication that is altered by the liver. Some drugs that are metabolized by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.

Drugs Driven by Cell Pumps (P-glycoprotein substrates):

Some drugs are powered by pumps in cells. Black and white pepper can make these pumps less active and increase how well some drugs are absorbed by the body. This can potentiate the side effects of some medications.

Some drugs that are powered by these pumps include etoposide, paclitaxel, vinblastine, vincristine, vindesine, ketoconazole, itraconazole, amprenavir, indinavir, nelfinavir, saquinavir, cimetidine, ranitidine , diltiazem, verapamil , digoxin, corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine and others.

Fenitoina (Dilantin): 

Black and white pepper can increase the amount of phenytoin (Dilantin) the body absorbs. Taking black and white pepper along with phenytoin (Dilantin) can increase the side effects of phenytoin (Dilantin).

Propranolol (Inderal):

Black and white pepper can increase how much propranolol (Inderal) the body absorbs. Taking black and white pepper along with propranolol (Inderal) may increase the side effects of propranolol (Inderal).


Both types of peppers can increase the amount of rifampicin the body absorbs. Taking black and white pepper along with rifampicin can increase the side effects of rifampicin.


Black pepper and white pepper can increase the amount of theophylline the body can absorb. This can potentiate theophylline side effects.

Carbamazepina (Tegretol): 

Black and white pepper can increase the amount of carbamazepine (Tegretol) absorbed by the body. It can also decrease how quickly the body breaks down and eliminates carbamazepine. This can increase the amount of carbamazepine in the body and potentially increase the chance of side effects.

Black Pepper and White Pepper → Dosage: 

The appropriate dose of  black pepper and white pepper  to use as a treatment depends on a number of factors such as age, health, and various other conditions. At this time, there is no scientific information that determines an appropriate dose for each pepper variety.

Keep in mind that natural products are not always safe and dosages can be important.

Useful links: 

Follow relevant instructions on product labels and consult your pharmacist, physician or other healthcare professional before use.

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